Doctor Thaddeus S. "Rusty" Venture is the current owner and head of Venture Industries. He lives and travels with his sons Hank Venture and Dean Venture and his bodyguard Brock Samson, and later with Sergeant Hatred, in the Venture Compound.
As a child (and presumably until entering college) he was called Rusty Venture, and was famous (in a cartoon show based on his real life) as a boy adventurer. While attending State university, he decided to go by his initials instead, and asked to be called T. S. Venture, possibly as a nod to writer T. S. Eliot. Today, he is commonly called Dr. Venture, although some of his older acquaintances may refer to him as T. S. or Rusty.
Although the son of famed superscientist Dr. Jonas Venture, Dr. Venture does not seem to have inherited his father's technological or adventuring skills. He has few working inventions of his own, and relies heavily on his late father's inventions to pay the bills as well as for everyday use. His lack of income forced him to sell many of his father's inventions at a 'tag sale', as seen in Tag-Sale -- You're it!. One of his more recent inventions that we've seen is the Vacuum Boom-Vroom, which he ended up cuddling with when he couldn't meet any "hot, desperate women." Several flashbacks (generally resulting in the popping of a "diet pill" to end the memory) suggest that his romantic childhood "adventuring" with his father was actually severely traumatic, affecting him negatively to the present day. The general aura of desperation, mediocrity and failure which sharply differentiates Dr. Venture from his famous, masculine and larger-than-life father provides much of the fodder for the show's plot. It was revealed that Dr. Venture is not really a Dr., having never earned a doctorate in anything. In fact, his undergraduate studies were cut short and he does not appear to have continued his formal studies- instead receiving an honorary degree from what he described as a "small, rather exclusive" institution in Tijuana.
Rusty, Brock, Pete White, Mike Sorayama, Baron Ünderbeiht and The Monarch all went to the same college, State University at the same time. Brock was Rusty's roommates but they never talked while they were roommates. Rusty found out about his father's Jonas death while in college.
The identity of Hank and Dean's mother remains unknown, although Venture's first bodyguard Myra Brandish has claimed to be their mother in I Know Why the Caged Bird Kills. It is possible that Hank and Dean have no actual mother; they may have been grown completely in a laboratory. Dr. Venture refers to the boys having been through a 'prototype phase' in Are You There God? It's Me, Dean, but he may have been referring solely to clone slug development and not their actual creation. The fact that Dr. Venture claims to have lost his virginity at 24, may add credence to the theory that Myra Brandish is actually the boys' mother.
Dr. Venture was seduced by Dr. Girlfriend in Mid-Life Chrysalis as part of a plan hatched by The Monarch, though she continually denies they actually had sex, or else forgets the incident as is convenient. He was also the target of Sally Impossible's misguided attempt to escape the suffocating grasp of her husband Richard Impossible (Ice Station -- Impossible!) and was subsequently used by Venture in a plot to retrieve a part of an invention of his father's in Twenty Years to Midnight. When Sally voices her obsessive desire to run away with him and leave her husband, he rebukes her by secretly fleeing the scene in the X-1, leaving Sally in tears. He himself has found his tactless advances violently rebuffed by both Molotov Cocktease and Hunter Gathers on separate occasions. When he finally comes close to relieving some pent-up sexual frustration with childhood friend Dr. Quymn (even immediately recalling from memory the number of years, months and days he has gone without female companionship), the two are interrupted by a rampaging Ginnie, with Dr. Quymn's resultant seizure causing him to lose interest in her. In season 4 it was revealed he slept with Dermott Fictel's biological mother Nikki when she was 15 after she lied about her age. Judging by his hairline in Everybody Comes To Hank's and his hairline in I Know Why The Caged Bird Kills and The Invisible Hand Of Fate his encounter with Nikki most likely occurred after he slept with Myra or the birth of the twins.
Dr. Venture is addicted to "diet pills", which he keeps constantly on his person in a metal tin and uses conspicuously on several occasions to quiet his painful traumatic memories and semi-frequent hallucinations revolving around his dysfunctional childhood and unresolved issues with his dead father. He has also had a variety of medical problems; in Dia de Los Dangerous, he had both of his kidneys removed. Later, in Return to Spider-Skull Island, he has a "tumor" removed, only to find out that it was actually his twin brother, Jonas Venture Jr..
- Neither of his kidneys are actually his. He took one from both Hank and Dean.
- In Showdown at Cremation Creek (Part 2) Dr. Venture can be seen in Dean's Everlasting Breakdown as the Lab Rat, an assistant to Pete White | The White Oracle.
- Has been buried alive five or six times in his life.
- Most if not all the women Dr. Venture has been involved with (or that find him attractive) have some form of mental instability (Myra Brandish, Sally Impossible, Dr. Quymn & Nikki Fictel)
- The "Rusty Venture" is also a sex act though what exactly is open to debate.
- Dermott Fictel is Rusty's illegitimate son. Rusty slept with Nikki Fictel the 15 year old chairman of the Rusty Venture Fan Club after she lied about her age. Dermot was raised to believe his mother was his sister, his grandmother was his mother and that his father lived at the Venture compound (Dermott mistakenly thought Brock was his father). Hank has also slept with Nikki. Judging by Rusty's hairline Dermott was born after Hank and Dean but may appear older because of the constant use of cloning offsetting Hank and Dean's real age.
- Rusty's great-grandfather was a milliner.
- Rusty's grandfather Lloyd Venture was in the Guild before it became the Guild of Calamitous Intent.
- Jonas Venture made Rusty kill a man with a house key when he was 10.